Hyperhomocysteinemia also determines Nitric Oxide (NO) metabolism impairment in endothelial cells (including Nitric Oxide Synthase expression, localization, activation, and activity) leading, together with ROS-induced local microinflammation, to endothelial dysfunction [39]
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Sperm DNA fragmentation measured by sperm chromatin dispersion impacts morphokinetic parameters, fertilization rate and blastocyst quality in ICSI treatments
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Endothelial dysfunction: mechanisms and contribution to diseases